Author: paroukatos

Athanasios J. Manolisa, John L. Reidb, Dick de Zeeuwc, Michael B. Murphyd, Elke Seewaldt-Beckere and Ju¨ rgen Ko¨ sterf on behalf  of the ARAMIS Study Group Objective: To identify telmisartan doses that are more effective than placebo and non-inferior to hydrochlorothiazide (HCTZ) 12.5 mg, and are well...

A Morbidity and Mortality Study CAMELOT: Primary End Point Time to first composite major CV event (MACE): CV death Nonfatal MI Resuscitated cardiac arrest Need for coronary revascularization Hospitalization for: Angina CHF PVD procedure Stoke (fatal or nonfatal) or TIA PVD (new diagnosis) CAMELOT: Secondary End Points   ...

Principal Investigator: Carl J. Pepine, MD Division of Cardiovascular Medicine University of Florida College of Medicine Gainesville, Florida USA What Is INVEST? INVEST (the INternational VErapamil SR and Trandolapril STudy) is the first randomized, prospective trial to exclusively study patients with hypertension and coronary artery disease (CAD). INVEST is also the first...

Ο σχεδιασμός της μελέτης Για πρώτη φορά μέχρι σήμερα, σχεδιάστηκε μία τέτοιου μεγέθους, τυχαιοποιημένη και ελεγχόμενη με τη χορήγηση εικονικού φαρμάκου μελέτη, προκειμένου να αξιολογήσει τα κλινικά αποτελέσματα της χορήγησης ενός αντιστηθαγχικού φαρμάκου σε ασθενείς με συμπτωματική σταθερή στηθάγχη. Σχεδιάστηκε με σκοπό να αξιολογήσει την...

Liffert Vogta, Gerjan Navisa, Ju¨ rgen Ko¨ sterb, Athanasios J. Manolisc, John L. Reidd, Dick de Zeeuwa and on behalf of the Angiotensin II Receptor Antagonist Telmisartan Micardis in Isolated Systolic Hypertension (ARAMIS) Study Group Objective: To examine the effect of telmisartan or hydrochlorothiazide on the control...

Ralf A. Benndorf4, Tanja Rudolph, Daniel Appel, Edzard Schwedhelm, Renke Maas, Friedrich Schulze, Elisabeth Silberhorn, Rainer H. Bfger Institute of Experimental and Clinical Pharmacology and Toxicology, Department of Clinical Pharmacology, University Hospital Hamburg-Eppendorf, D-20246 Hamburg, Germany Received 18 January 2006; accepted 18 April 2006 Abstract Hypertension is a...

A.M. Sharma1, A. Hollander2 and J. Köster3 1University Clinic Benjamin Franklin, Freie Universität, Berlin, 2Bosch Medicentrum, Den Bosch, The Netherlands, and 3Boehringer Ingelheim Pharma KG, Ingelheim, Germany, on behalf of the Efficacy and Safety in Patients with Renal Impairment treated with Telmisartan (ESPRIT) Study Group Abstract. Aims: This study as sessed the...

Ronald Clasen, Michael Schupp, Anna Foryst-Ludwig, Christiane Sprang, Markus Clemenz, Maxim Krikov, Christa Tho¨ne-Reineke, Thomas Unger, Ulrich Kintscher Abstract The adipose-specific protein adiponectin has been recently discovered to improve insulin sensitivity. Angiotensin type-1 receptor (AT1R) blockers (ARBs) reduce the incidence of type 2 diabetes mellitus by mostly...