Author: paroukatos

Oscar H Franco, Luc Bonneux, Chris de Laet, Anna Peeters, Ewout W Steyerberg and Johan P MackenbachAbstract Objective: Although the Polypill concept (proposed in 2003) is promising in terms of benefits for cardiovascular risk management, the potential costs and adverse effects are its main pitfalls. The objective...

Aled W. Robertsa, Andrew Thomasb, Alan Reesa and Marc Evansa Purpose of review  The prevalence of type 2 diabetes globally is reaching epidemic proportions. Type 2 diabetes is strongly associated with increased risk of cardiovascular disease. Atherosclerosis is thought to arise as a result of a chronic...

Abstract Diabetic nephropathy is characterised by hypertension and persistent proteinuria. If ineffectively controlled, a progressive decline in renal function can result in end-stage renal disease. Patients with diabetic nephropathy are also at greatly increased risk of cardiovascular disease. Angiotensin-converting enzyme (ACE) inhibitors display additional renoprotective effects...

Peter Kokkinos, Andreas Pittaras, Athanasios Manolis, Demosthenes Panagiotakos, Puneet Narayan, Demitra Manjoros, Richard L. Amdur, and Steven Singh Background: Prehypertensive individuals are at increased risk for developing hypertension and cardiovascular disease compared to those with normal blood pressure (BP). Physically active, normotensive individuals are also at...

Peter Kokkinos, Andreas Pittaras, Puneet Narayan, Charles Faselis, Steven Singh, Athanasios Manolis Abstract Prehypertensive individuals are at increased risk for developing hypertension and cardiovascular disease compared with those with normal blood pressure. Early compromises in left ventricular structure may explain part of the increased risk. We assessed...

The replacement of angiotensin converting enzyme inhibition (REPLACE) investigators P.H.J.M. Dunselman* Working Group on Cardiovascular Research ( WCN), 87 Baronielaan, 4818 PC Breda, The Netherlands Received 22 March 2000; received in revised form 21 August 2000; accepted 4 September 2000 Abstract Aim: To compare the effects on maximal exercise tolerance...

Steen Neldam, MD, PhD;1 Colin Edwards, PhD;2 on behalf of the ATHOS Study Group* From Rodøvre Centrum, Denmark;1 and  Boehringer Ingelheim Ireland Ltd, Dublin, Ireland2 *ATHOS Study Group members are listed in the Appendix. Address for correspondence: Steen Neldam, MD, Rodøvre Centrum 294, 2610 Rodøvre, Denmark E-mail: neldam@dadlnet.dk Manuscript...

Norman M. KaplanJournal of Hypertension 2006, 24:211-214 The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA Correspondence and requests for reprints to Norman M. Kaplan, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-8899, USA  Tel: +1 214 6482103; fax: +1 214 6487979; e-mail: norman.kaplan@utsouth-western.ed The results of...