Hypertension and Arrhythmias

Hypertension and Arrhythmias


  • Hypertension is one of the earliest recorded medical conditions (2.600BC)
  • Consequences of hypertension will soon be the leading global cause of death
  • The risk of death increases with increasing SBP
  • On one hand is a risk factor for the development of coronary artery disease, and on the other hand for the incidence of ventricular arrhythmias or even cardiac death.


Arrhythmogenic Mechanisms in Hypertension

  • Duration of the action potential is increased
  • The plateau phase of the action potential is more labile than non-LVH
  • Disorders of the cytosolic calcium concentrations
  • The normal regional differences of action potential duration are reversed
  • Reentry seems to be directly linked with fibrosis
  • Link of LV wall stress and arrhythmias
  • The HRV is decreased
  • Electrolyte imbalance such as disorders of calcium and potassium channels


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